| ITF W75 Caserta | 06/06 09:45 | 26 | [229] Despina Papamichail v Amandine Hesse [275] | 2-6,0-6 | |
| ITF W75 Caserta | 06/05 08:30 | 25 | [229] Despina Papamichail v Dalila Spiteri [319] | 6-4,6-1 | |
| French Open Women | 05/21 11:25 | 14 | [235] Despina Papamichail v Daria Snigur [123] | 5-7,2-6 | |
| ITF W100 Madrid | 05/15 08:50 | 25 | [221] Xiaodi You v Despina Papamichail [231] | 7-6,6-2 | |
| ITF W100 Madrid | 05/13 10:35 | 54 | [231] Despina Papamichail v Martyna Kubka [351] | 7-6,6-3 | |
| ITF W100 Madrid | 05/12 11:45 | 54 | Despina Papamichail v Paula Arias Manjon | 6-2,6-7,6-2 | |
| ITF W75 Prague | 05/08 08:50 | 25 | [305] Jaimee Fourlis v Despina Papamichail [231] | 6-4,7-6 | |
| WTA Lleida | 05/01 08:00 | 25 | [237] Despina Papamichail v Magdalena Frech [51] | 2-6,4-6 | |
| WTA Lleida | 04/30 10:25 | 14 | [237] Despina Papamichail v Yvonne Cavalle-Reimers [293] | 6-4,6-0 | |
| ITF W75 Chiasso | 04/17 12:30 | 25 | [235] Despina Papamichail v Maria Sara Popa [432] | 7-5,5-7,6-7 | |
| Billie Jean King Cup | 04/09 10:00 | 1 | [111] Aleksandra Krunic v Despina Papamichail [235] | 6-0,6-3 | |
| Billie Jean King Cup | 04/08 09:50 | 1 | [469] Kajsa Rinaldo Persson v Despina Papamichail [235] | 4-6,4-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.